There was a time when an XT-class motherboard — like the old IBM PC with an 8088 CPU — was a high-tech accomplishment. Now, something like that is easily within reach of the average hobby lab. [Homebrew8088] did it, and it looks surprisingly simple, especially compared to what passes for a motherboard these days.
The board will take an 8088 or one of the NEC chips and by default sports 512 K of RAM, a few ISA slots, a PC speaker, a USB hard drive, and a PS/2 keyboard connector. The board will fit in an ATX case. Not bad. You can see a video of the board below.
In fact, the channel has a lot of related videos and the main site has many interesting topics, like driving an 8088 or 8086 from a Raspberry Pi. The GitHub site has design files for KiCad along with a lot of other information. Some of this will be interesting even if you are just trying to repair an old motherboard or would like to design a new ISA card.